6FE0
Three dimensional structure of human carbonic anhydrase IX in complex with benzenesulfonamide.
Summary for 6FE0
Entry DOI | 10.2210/pdb6fe0/pdb |
Descriptor | Carbonic anhydrase 9, ZINC ION, 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)sulfanyl]benzenesulfonamide, ... (4 entities in total) |
Functional Keywords | lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 114602.34 |
Authors | Leitans, J.,Tars, K. (deposition date: 2017-12-28, release date: 2018-07-04, Last modification date: 2024-01-17) |
Primary citation | Kazokaite, J.,Niemans, R.,Dudutiene, V.,Becker, H.M.,Leitans, J.,Zubriene, A.,Baranauskiene, L.,Gondi, G.,Zeidler, R.,Matuliene, J.,Tars, K.,Yaromina, A.,Lambin, P.,Dubois, L.J.,Matulis, D. Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells. Oncotarget, 9:26800-26816, 2018 Cited by PubMed: 29928486DOI: 10.18632/oncotarget.25508 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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