6F96

Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-[(4-methoxyphenyl)amino]-N-(pyridin-3-yl)pyridine-3-carboxamide

Summary for 6F96

• Entry DOI: 10.2210/pdb6f96/pdb
• Descriptor: DNA gyrase subunit B, 6-(ethylcarbamoylamino)-4-[(4-methoxyphenyl)amino]-~{N}-pyridin-3-yl-pyridine-3-carboxamide (3 entities in total)
• Functional Keywords: binding sites, dna gyrase, inhibitors, pyridine-3-carboxamides, topoisomerase iv, isomerase
• Biological source: Escherichia coli O157:H7
• Total number of polymer chains: 1
• Total formula weight: 24684.70

Authors

Narramore, S.K.,Stevenson, C.E.M.,Lawson, D.M.,Maxwell, A.,Fishwick, C.W.G. (deposition date: 2017-12-14, release date: 2019-01-30, Last modification date: 2024-01-17)

• Primary citation: Narramore, S.,Stevenson, C.E.M.,Maxwell, A.,Lawson, D.M.,Fishwick, C.W.G.; New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.; Bioorg.Med.Chem., 27:3546-3550, 2019; PubMed: 31257079; DOI: 10.1016/j.bmc.2019.06.015

Experimental method

X-RAY DIFFRACTION (2.5 Å)