6F8J

Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-(1H-pyrazol-1-yl)-N-(pyridin-3-yl)pyridine-3-carboxamide

6F8J の概要

• エントリーDOI: 10.2210/pdb6f8j/pdb
• 分子名称: DNA gyrase subunit B, 6-(ethylcarbamoylamino)-4-pyrazol-1-yl-~{N}-pyridin-3-yl-pyridine-3-carboxamide (3 entities in total)
• 機能のキーワード: binding sites, dna gyrase, inhibitors, pyridine-3-carboxamides, topoisomerase iv, isomerase
• 由来する生物種: Escherichia coli O157:H7
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24629.62

構造登録者

Narramore, S.K.,Stevenson, C.E.M.,Lawson, D.M.,Maxwell, A.,Fishwick, C.W.G. (登録日: 2017-12-13, 公開日: 2019-06-26, 最終更新日: 2024-01-17)

• 主引用文献: Narramore, S.,Stevenson, C.E.M.,Maxwell, A.,Lawson, D.M.,Fishwick, C.W.G.; New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.; Bioorg.Med.Chem., 27:3546-3550, 2019; PubMed: 31257079; DOI: 10.1016/j.bmc.2019.06.015

実験手法

X-RAY DIFFRACTION (1.95 Å)