6F5M
Crystal structure of highly glycosylated human leukocyte elastase in complex with a thiazolidinedione inhibitor
Summary for 6F5M
Entry DOI | 10.2210/pdb6f5m/pdb |
Descriptor | Neutrophil elastase, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | human leukocyte elastase, human neutrophil elastase, parabolic inhibition, glycosylation, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 51575.68 |
Authors | Hochscherf, J.,Pietsch, M.,Tieu, W.,Kuan, K.,Hautmann, S.,Abell, A.,Guetschow, M.,Niefind, K. (deposition date: 2017-12-01, release date: 2018-08-08, Last modification date: 2024-01-17) |
Primary citation | Hochscherf, J.,Pietsch, M.,Tieu, W.,Kuan, K.,Abell, A.D.,Gutschow, M.,Niefind, K. Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor. Acta Crystallogr F Struct Biol Commun, 74:480-489, 2018 Cited by PubMed: 30084397DOI: 10.1107/S2053230X1800537X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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