6F5M

Crystal structure of highly glycosylated human leukocyte elastase in complex with a thiazolidinedione inhibitor

6F5M の概要

• エントリーDOI: 10.2210/pdb6f5m/pdb
• 分子名称: Neutrophil elastase, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: human leukocyte elastase, human neutrophil elastase, parabolic inhibition, glycosylation, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51575.68

構造登録者

Hochscherf, J.,Pietsch, M.,Tieu, W.,Kuan, K.,Hautmann, S.,Abell, A.,Guetschow, M.,Niefind, K. (登録日: 2017-12-01, 公開日: 2018-08-08, 最終更新日: 2024-01-17)

• 主引用文献: Hochscherf, J.,Pietsch, M.,Tieu, W.,Kuan, K.,Abell, A.D.,Gutschow, M.,Niefind, K.; Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor.; Acta Crystallogr F Struct Biol Commun, 74:480-489, 2018; PubMed: 30084397; DOI: 10.1107/S2053230X1800537X

実験手法

X-RAY DIFFRACTION (2.7 Å)