6F26
Crystal structure of human Casein Kinase I delta in complex with compound 31b
Summary for 6F26
Entry DOI | 10.2210/pdb6f26/pdb |
Descriptor | Casein kinase I isoform delta, SULFATE ION, (9~{S},10~{S},11~{R})-~{N}-[4-[3-(4-fluorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]pyridin-2-yl]-4-(4-methoxyphenyl)-10,11-bis(oxidanyl)-1,7-diazatricyclo[7.3.0.0^{3,7}]dodeca-3,5-diene-6-carboxamide, ... (4 entities in total) |
Functional Keywords | kinase, inhibitor, complex, ck1, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 75828.32 |
Authors | Pichlo, C.,Brunstein, E.,Baumann, U. (deposition date: 2017-11-23, release date: 2019-03-13, Last modification date: 2024-01-17) |
Primary citation | Luxenburger, A.,Schmidt, D.,Ianes, C.,Pichlo, C.,Kruger, M.,von Drathen, T.,Brunstein, E.,Gainsford, G.J.,Baumann, U.,Knippschild, U.,Peifer, C. Design, Synthesis and Biological Evaluation of Isoxazole-Based CK1 Inhibitors Modified with Chiral Pyrrolidine Scaffolds. Molecules, 24:-, 2019 Cited by PubMed: 30832206DOI: 10.3390/molecules24050873 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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