6F26

Crystal structure of human Casein Kinase I delta in complex with compound 31b

6F26 の概要

• エントリーDOI: 10.2210/pdb6f26/pdb
• 分子名称: Casein kinase I isoform delta, SULFATE ION, (9~{S},10~{S},11~{R})-~{N}-[4-[3-(4-fluorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]pyridin-2-yl]-4-(4-methoxyphenyl)-10,11-bis(oxidanyl)-1,7-diazatricyclo[7.3.0.0^{3,7}]dodeca-3,5-diene-6-carboxamide, ... (4 entities in total)
• 機能のキーワード: kinase, inhibitor, complex, ck1, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75828.32

構造登録者

Pichlo, C.,Brunstein, E.,Baumann, U. (登録日: 2017-11-23, 公開日: 2019-03-13, 最終更新日: 2024-01-17)

• 主引用文献: Luxenburger, A.,Schmidt, D.,Ianes, C.,Pichlo, C.,Kruger, M.,von Drathen, T.,Brunstein, E.,Gainsford, G.J.,Baumann, U.,Knippschild, U.,Peifer, C.; Design, Synthesis and Biological Evaluation of Isoxazole-Based CK1 Inhibitors Modified with Chiral Pyrrolidine Scaffolds.; Molecules, 24:-, 2019; PubMed: 30832206; DOI: 10.3390/molecules24050873

実験手法

X-RAY DIFFRACTION (1.83 Å)