Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6F20

Complex between MTH1 and compound 1 (a 7-azaindole-4-ester derivative)

Summary for 6F20
Entry DOI10.2210/pdb6f20/pdb
Descriptor7,8-dihydro-8-oxoguanine triphosphatase, Ethyl 1H-pyrrolo[2,3-b]pyridine-4-carboxylate, SULFATE ION, ... (6 entities in total)
Functional Keywordsnudix, nucleotide hydrolase, inhibitor, oncology, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationIsoform p18: Cytoplasm. Isoform p26: Cytoplasm: P36639
Total number of polymer chains2
Total formula weight37733.47
Authors
Viklund, J.,Talagas, A.,Tresaugues, L.,Andersson, M.,Ericsson, U.,Forsblom, R.,Ginman, T.,Hallberg, K.,Lindstrom, J.,Persson, L.,Silvander, C.,Rahm, F. (deposition date: 2017-11-23, release date: 2018-03-07, Last modification date: 2024-01-17)
Primary citationRahm, F.,Viklund, J.,Tresaugues, L.,Ellermann, M.,Giese, A.,Ericsson, U.,Forsblom, R.,Ginman, T.,Gunther, J.,Hallberg, K.,Lindstrom, J.,Persson, L.B.,Silvander, C.,Talagas, A.,Diaz-Saez, L.,Fedorov, O.,Huber, K.V.M.,Panagakou, I.,Siejka, P.,Gorjanacz, M.,Bauser, M.,Andersson, M.
Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.
J. Med. Chem., 61:2533-2551, 2018
Cited by
PubMed: 29485874
DOI: 10.1021/acs.jmedchem.7b01884
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

数据于2024-03-27公开中

PDB statisticsPDBj update infoContact PDBjnumon