6F0C
Cytochrome P450 TxtC employs substrate conformational switching for sequential aliphatic and aromatic thaxtomin hydroxylation
6F0C の概要
エントリーDOI | 10.2210/pdb6f0c/pdb |
分子名称 | Cytochrome P450 monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, (3~{R},6~{S})-1,4-dimethyl-6-[(4-nitro-1~{H}-indol-3-yl)methyl]-3-oxidanyl-3-(phenylmethyl)piperazine-2,5-dione, ... (5 entities in total) |
機能のキーワード | cytochrome p450, txtc, thaxtomin hydroxylation, oxidoreductase |
由来する生物種 | Streptomyces acidiscabies 84-104 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 44542.30 |
構造登録者 | |
主引用文献 | Alkhalaf, L.M.,Barry, S.M.,Rea, D.,Gallo, A.,Griffiths, D.,Lewandowski, J.R.,Fulop, V.,Challis, G.L. Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC. J.Am.Chem.Soc., 141:216-222, 2019 Cited by PubMed: 30516965DOI: 10.1021/jacs.8b08864 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.7 Å) |
構造検証レポート
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