6EZ9

X-ray structure of human glutamate carboxypeptidase II (GCPII) - the E424M inactive mutant, in complex with a inhibitor JHU3372

6EZ9 の概要

• エントリーDOI: 10.2210/pdb6ez9/pdb
• 分子名称: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: glutamate carboxypeptidase ii (gcpii); naaladase; prostate-specific membrane antigen; phosphoramidate, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 83138.25

構造登録者

Barinka, C.,Novakova, Z.,Motlova, L. (登録日: 2017-11-14, 公開日: 2018-12-12, 最終更新日: 2024-01-17)

• 主引用文献: Barinka, C.,Novakova, Z.,Hin, N.,Bim, D.,Ferraris, D.V.,Duvall, B.,Kabarriti, G.,Tsukamoto, R.,Budesinsky, M.,Motlova, L.,Rojas, C.,Slusher, B.S.,Rokob, T.A.,Rulisek, L.,Tsukamoto, T.; Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors.; Bioorg.Med.Chem., 27:255-264, 2019; PubMed: 30552009; DOI: 10.1016/j.bmc.2018.11.022

実験手法

X-RAY DIFFRACTION (1.61 Å)