6EXY

Neutron crystal structure of perdeuterated galectin-3C in complex with glycerol

6EXY の概要

• エントリーDOI: 10.2210/pdb6exy/pdb
• 分子名称: Galectin-3, GLYCEROL (3 entities in total)
• 機能のキーワード: galectin, hydrogen bonding, molecular recognition, perdeuteration, sugar binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15924.34

構造登録者

Manzoni, F.,Schrader, T.E.,Ostermann, A.,Oksanen, E.,Logan, D.T. (登録日: 2017-11-10, 公開日: 2018-09-12)

• 主引用文献: Manzoni, F.,Wallerstein, J.,Schrader, T.E.,Ostermann, A.,Coates, L.,Akke, M.,Blakeley, M.P.,Oksanen, E.,Logan, D.T.; Elucidation of Hydrogen Bonding Patterns in Ligand-Free, Lactose- and Glycerol-Bound Galectin-3C by Neutron Crystallography to Guide Drug Design.; J. Med. Chem., 61:4412-4420, 2018; PubMed: 29672051; DOI: 10.1021/acs.jmedchem.8b00081

実験手法

NEUTRON DIFFRACTION (1.7 Å)
X-RAY DIFFRACTION (1.1 Å)