6EUC

Reactivating oxime bound to Tc AChE's catalytic gorge.

6EUC の概要

• エントリーDOI: 10.2210/pdb6euc/pdb
• 分子名称: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-[(~{E})-hydroxyiminomethyl]-6-(5-morpholin-4-ylpentyl)pyridin-3-ol, ... (5 entities in total)
• 機能のキーワード: acetylcholinesterase, reactivator, aldehyde oxime, organophosphate poisoning, hydrolase
• 由来する生物種: Tetronarce californica (Pacific electric ray)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 66987.41

構造登録者

de la Mora, E.,Weik, M.,Braiki, A.,Mougeot, R.,Jean, L.,Renard, P.I. (登録日: 2017-10-30, 公開日: 2018-11-14, 最終更新日: 2020-07-29)

• 主引用文献: Zorbaz, T.,Braiki, A.,Marakovic, N.,Renou, J.,de la Mora, E.,Macek Hrvat, N.,Katalinic, M.,Silman, I.,Sussman, J.L.,Mercey, G.,Gomez, C.,Mougeot, R.,Perez, B.,Baati, R.,Nachon, F.,Weik, M.,Jean, L.,Kovarik, Z.,Renard, P.Y.; Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration.; Chemistry, 24:9675-9691, 2018; PubMed: 29672968; DOI: 10.1002/chem.201801394

実験手法

X-RAY DIFFRACTION (2.21998854547 Å)