6EUB

The fibrinogen-like domain of human Angptl4

6EUB の概要

• エントリーDOI: 10.2210/pdb6eub/pdb
• 関連するPDBエントリー: 6EUA
• 分子名称: Angiopoietin-related protein 4, PENTAETHYLENE GLYCOL (3 entities in total)
• 機能のキーワード: lipid metabolism, plasma triglyceride, angiopoietin-like, coronary artery disease, signaling protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted : Q9BY76
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26401.63

構造登録者

Biterova, E.I.,Esmaeeli, M.,Alanen, H.I.,Saaranen, M.,Ruddock, L.W. (登録日: 2017-10-30, 公開日: 2018-05-09, 最終更新日: 2024-10-09)

主引用文献

Biterova, E.,Esmaeeli, M.,Alanen, H.I.,Saaranen, M.,Ruddock, L.W.
Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease.
Sci Rep, 8:6752-6752, 2018

PubMed Abstract: Coronary artery disease is the most common cause of death globally and is linked to a number of risk factors including serum low density lipoprotein, high density lipoprotein, triglycerides and lipoprotein(a). Recently two proteins, angiopoietin-like protein 3 and 4, have emerged from genetic studies as being factors that significantly modulate plasma triglyceride levels and coronary artery disease. The exact function and mechanism of action of both proteins remains to be elucidated, however, mutations in these proteins results in up to 34% reduction in coronary artery disease and inhibition of function results in reduced plasma triglyceride levels. Here we report the crystal structures of the fibrinogen-like domains of both proteins. These structures offer new insights into the reported loss of function mutations, the mechanisms of action of the proteins and open up the possibility for the rational design of low molecular weight inhibitors for intervention in coronary artery disease.

PubMed: 29713054
DOI: 10.1038/s41598-018-25237-7

実験手法

X-RAY DIFFRACTION (2.3 Å)