6ESM

Crystal structure of MMP9 in complex with inhibitor BE4.

Summary for 6ESM

Entry DOI	10.2210/pdb6esm/pdb
Related	5I12 6ELA
Descriptor	Matrix metalloproteinase-9,Matrix metalloproteinase-9, ZINC ION, CALCIUM ION, ... (6 entities in total)
Functional Keywords	metzincin, carboxylate inhibitor alternative zinc-binding groups, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	18663.56
Authors	Ciccone, L.,Tepshi, L.,Nuti, E.,Rossello, A.,Stura, E.A. (deposition date: 2017-10-23, release date: 2018-05-16, Last modification date: 2024-01-17)
Primary citation	Nuti, E.,Cuffaro, D.,Bernardini, E.,Camodeca, C.,Panelli, L.,Chaves, S.,Ciccone, L.,Tepshi, L.,Vera, L.,Orlandini, E.,Nencetti, S.,Stura, E.A.,Santos, M.A.,Dive, V.,Rossello, A. Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies. J. Med. Chem., 61:4421-4435, 2018 Cited by PubMed: 29727184 DOI: 10.1021/acs.jmedchem.8b00096 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.104 Å)

Structure validation