6ESM

Crystal structure of MMP9 in complex with inhibitor BE4.

6ESM の概要

• エントリーDOI: 10.2210/pdb6esm/pdb
• 関連するPDBエントリー: 5I12 6ELA
• 分子名称: Matrix metalloproteinase-9,Matrix metalloproteinase-9, ZINC ION, CALCIUM ION, ... (6 entities in total)
• 機能のキーワード: metzincin, carboxylate inhibitor alternative zinc-binding groups, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18663.56

構造登録者

Ciccone, L.,Tepshi, L.,Nuti, E.,Rossello, A.,Stura, E.A. (登録日: 2017-10-23, 公開日: 2018-05-16, 最終更新日: 2024-01-17)

• 主引用文献: Nuti, E.,Cuffaro, D.,Bernardini, E.,Camodeca, C.,Panelli, L.,Chaves, S.,Ciccone, L.,Tepshi, L.,Vera, L.,Orlandini, E.,Nencetti, S.,Stura, E.A.,Santos, M.A.,Dive, V.,Rossello, A.; Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies.; J. Med. Chem., 61:4421-4435, 2018; PubMed: 29727184; DOI: 10.1021/acs.jmedchem.8b00096

実験手法

X-RAY DIFFRACTION (1.104 Å)