6EQW
X-ray structure of the proprotein convertase furin bound with the competitive inhibitor 4-aminomethyl-phenylacetyl-Arg-Val-Arg-Amba
Summary for 6EQW
Entry DOI | 10.2210/pdb6eqw/pdb |
Descriptor | Furin, AMA-ARG-TBG-ARG-00S, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | protease, inhibitor, proprotein convertase, hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Golgi apparatus, trans-Golgi network membrane ; Single- pass type I membrane protein : P09958 |
Total number of polymer chains | 2 |
Total formula weight | 53360.16 |
Authors | Dahms, S.O.,Than, M.E. (deposition date: 2017-10-16, release date: 2018-02-28, Last modification date: 2024-01-17) |
Primary citation | Dahms, S.O.,Hardes, K.,Steinmetzer, T.,Than, M.E. X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket. Biochemistry, 57:925-934, 2018 Cited by PubMed: 29314830DOI: 10.1021/acs.biochem.7b01124 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.994 Å) |
Structure validation
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