6EQ6
MTH1 in complex with fragment 1
Summary for 6EQ6
Entry DOI | 10.2210/pdb6eq6/pdb |
Descriptor | 7,8-dihydro-8-oxoguanine triphosphatase, 3-pyrrolidin-1-ylquinoxalin-2-amine, ACETATE ION, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, hydrolase, dna repair, fragment |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 21474.30 |
Authors | Wiedmer, L.,Sledz, P.,Caflisch, A. (deposition date: 2017-10-12, release date: 2018-10-31, Last modification date: 2024-05-08) |
Primary citation | Wiedmer, L.,Scharer, C.,Spiliotopoulos, D.,Hurzeler, M.,Sledz, P.,Caflisch, A. Ligand retargeting by binding site analogy. Eur.J.Med.Chem., 175:107-113, 2019 Cited by PubMed: 31077996DOI: 10.1016/j.ejmech.2019.04.037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.002 Å) |
Structure validation
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