6ENQ

Structure of human PPAR gamma LBD in complex with Lanifibranor (IVA337)

6ENQ の概要

• エントリーDOI: 10.2210/pdb6enq/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, 4-[1-(1,3-benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl]butanoic acid (3 entities in total)
• 機能のキーワード: nuclear hormone receptor, ppargamma modulator, lanifibranor, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64853.47

構造登録者

Boubia, B.,Poupardin, O.,Barth, M.,Amaudrut, J.,Broqua, P.,Tallandier, M.,Zeyer, D. (登録日: 2017-10-06, 公開日: 2018-03-14, 最終更新日: 2024-01-17)

• 主引用文献: Boubia, B.,Poupardin, O.,Barth, M.,Binet, J.,Peralba, P.,Mounier, L.,Jacquier, E.,Gauthier, E.,Lepais, V.,Chatar, M.,Ferry, S.,Thourigny, A.,Guillier, F.,Llacer, J.,Amaudrut, J.,Dodey, P.,Lacombe, O.,Masson, P.,Montalbetti, C.,Wettstein, G.,Luccarini, J.M.,Legendre, C.,Junien, J.L.,Broqua, P.; Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) alpha / gamma / delta Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate.; J. Med. Chem., 61:2246-2265, 2018; PubMed: 29446942; DOI: 10.1021/acs.jmedchem.7b01285

実験手法

X-RAY DIFFRACTION (2.2 Å)