6EN6

Crystal structure B of the Angiotensin-1 converting enzyme N-domain in complex with a diprolyl inhibitor.

Summary for 6EN6

Entry DOI	10.2210/pdb6en6/pdb
Descriptor	Angiotensin-converting enzyme, MAGNESIUM ION, DI(HYDROXYETHYL)ETHER, ... (19 entities in total)
Functional Keywords	ace inhibitor, angiotensin-i converting enzyme, diprolyl inhibitor, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	304447.34
Authors	Cozier, G.E.,Acharya, K.R.,Fienberg, S.,Chibale, K.,Sturrock, E.D. (deposition date: 2017-10-04, release date: 2018-03-07, Last modification date: 2024-01-17)
Primary citation	Fienberg, S.,Cozier, G.E.,Acharya, K.R.,Chibale, K.,Sturrock, E.D. The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme. J. Med. Chem., 61:344-359, 2018 Cited by PubMed: 29206036 DOI: 10.1021/acs.jmedchem.7b01478 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation