6EN6

Crystal structure B of the Angiotensin-1 converting enzyme N-domain in complex with a diprolyl inhibitor.

6EN6 の概要

• エントリーDOI: 10.2210/pdb6en6/pdb
• 分子名称: Angiotensin-converting enzyme, MAGNESIUM ION, DI(HYDROXYETHYL)ETHER, ... (19 entities in total)
• 機能のキーワード: ace inhibitor, angiotensin-i converting enzyme, diprolyl inhibitor, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 304447.34

構造登録者

Cozier, G.E.,Acharya, K.R.,Fienberg, S.,Chibale, K.,Sturrock, E.D. (登録日: 2017-10-04, 公開日: 2018-03-07, 最終更新日: 2024-01-17)

• 主引用文献: Fienberg, S.,Cozier, G.E.,Acharya, K.R.,Chibale, K.,Sturrock, E.D.; The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme.; J. Med. Chem., 61:344-359, 2018; PubMed: 29206036; DOI: 10.1021/acs.jmedchem.7b01478

実験手法

X-RAY DIFFRACTION (1.8 Å)