6EMH

Crystal structure of JNK3 in complex with a pyridinylimidazole inhibitor

Summary for 6EMH

• Entry DOI: 10.2210/pdb6emh/pdb
• Descriptor: Mitogen-activated protein kinase 10, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... (9 entities in total)
• Functional Keywords: protein kinase activity map kinase activity atp binding protein phosphorylation, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 172197.76

Authors

Macedo, J.T.,Stehle, T.,Blaum, B.S. (deposition date: 2017-10-02, release date: 2018-08-08, Last modification date: 2024-01-17)

• Primary citation: Ansideri, F.,Macedo, J.T.,Eitel, M.,El-Gokha, A.,Zinad, D.S.,Scarpellini, C.,Kudolo, M.,Schollmeyer, D.,Boeckler, F.M.,Blaum, B.S.,Laufer, S.A.,Koch, P.; Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38 alpha Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3.; ACS Omega, 3:7809-7831, 2018; PubMed: 30087925; DOI: 10.1021/acsomega.8b00668

Experimental method