6EIS

DYRK1A in complex with JWC-055

6EIS の概要

• エントリーDOI: 10.2210/pdb6eis/pdb
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 1-[4-fluoranyl-2-(trifluoromethyl)phenyl]-9-(1~{H}-pyrazol-4-yl)benzo[h][1,6]naphthyridin-2-one (3 entities in total)
• 機能のキーワード: dual specificity tyrosine-phosphorylation-regulated kinase 1a, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 172313.37

構造登録者

Rothweiler, U. (登録日: 2017-09-19, 公開日: 2018-08-29, 最終更新日: 2024-01-17)

• 主引用文献: Czarna, A.,Wang, J.,Zelencova, D.,Liu, Y.,Deng, X.,Choi, H.G.,Zhang, T.,Zhou, W.,Chang, J.W.,Kildalsen, H.,Seternes, O.M.,Gray, N.S.,Engh, R.A.,Rothweiler, U.; Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.; J. Med. Chem., 61:7560-7572, 2018; PubMed: 30095246; DOI: 10.1021/acs.jmedchem.7b01847

実験手法

X-RAY DIFFRACTION (2.36 Å)