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6ECZ

Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.

6ECZ の概要
エントリーDOI10.2210/pdb6ecz/pdb
分子名称Carbonic anhydrase 2, ZINC ION, 1-[3-nitro-2-oxidanyl-5-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]sulfonyl-phenyl]-3-[2,3,4,5,6-pentakis(fluoranyl)phenyl]urea, ... (4 entities in total)
機能のキーワードhypoxia, carbonic anhydrase ix, carbonic anhydrase xii, inhibition, anti-proliferative., lyase, lyase-lyas inhibitor complex, lyase/lyas inhibitor
由来する生物種Homo sapiens (Human)
タンパク質・核酸の鎖数1
化学式量合計29471.32
構造登録者
Singh, S.,McKenna, R.,Supuran, C.T.,Nocentini, A.,Lomelino, C.,Lucarini, E.,Bartolucci, G.,Mannelli, L.D.C.,Ghelardini, C.,Gratteri, P. (登録日: 2018-08-08, 公開日: 2018-11-28, 最終更新日: 2023-10-11)
主引用文献Nocentini, A.,Trallori, E.,Singh, S.,Lomelino, C.L.,Bartolucci, G.,Di Cesare Mannelli, L.,Ghelardini, C.,McKenna, R.,Gratteri, P.,Supuran, C.T.
4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles.
J. Med. Chem., 61:10860-10874, 2018
Cited by
PubMed: 30433782
DOI: 10.1021/acs.jmedchem.8b01504
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.21 Å)
構造検証レポート
Validation report summary of 6ecz
検証レポート(詳細版)ダウンロードをダウンロード

217705

件を2024-03-27に公開中

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