6EBE
Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
6EBE の概要
エントリーDOI | 10.2210/pdb6ebe/pdb |
分子名称 | Carbonic anhydrase 2, ZINC ION, 4-hydroxy-3-nitro-5-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)benzene-1-sulfonamide, ... (4 entities in total) |
機能のキーワード | hypoxia, carbonic anhydrase ix, carbonic anhydrase xii, inhibition, anti-proliferative., lyase-lyase inhibitor complex, lyase/lyase inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 29418.37 |
構造登録者 | Singh, S.,McKenna, R.,Supuran, C.T.,Nocentini, A.,Lomelino, C.,Lucarini, E.,Bartolucci, G.,Mannelli, L.D.C.,Ghelardini, C.,Gratteri, P. (登録日: 2018-08-06, 公開日: 2018-11-28, 最終更新日: 2023-10-11) |
主引用文献 | Nocentini, A.,Trallori, E.,Singh, S.,Lomelino, C.L.,Bartolucci, G.,Di Cesare Mannelli, L.,Ghelardini, C.,McKenna, R.,Gratteri, P.,Supuran, C.T. 4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles. J. Med. Chem., 61:10860-10874, 2018 Cited by PubMed: 30433782DOI: 10.1021/acs.jmedchem.8b01504 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.88 Å) |
構造検証レポート
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