6E5A

PPARg in complex with compound 4b

Summary for 6E5A

Entry DOI	10.2210/pdb6e5a/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, (5Z)-5-({4-[(prop-2-yn-1-yl)oxy]phenyl}methylidene)-2-sulfanylidene-1,3-thiazolidin-4-one (3 entities in total)
Functional Keywords	ppar, nuclear receptor, transcription factor, ligand binding domain, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	63119.40
Authors	Bruning, J.B.,Chua, B.S.K. (deposition date: 2018-07-19, release date: 2019-03-13, Last modification date: 2023-10-11)
Primary citation	Elzahhar, P.A.,Alaaeddine, R.,Ibrahim, T.M.,Nassra, R.,Ismail, A.,Chua, B.S.K.,Frkic, R.L.,Bruning, J.B.,Wallner, N.,Knape, T.,von Knethen, A.,Labib, H.,El-Yazbi, A.F.,Belal, A.S.F. Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones. Eur J Med Chem, 167:562-582, 2019 Cited by PubMed: 30818268 DOI: 10.1016/j.ejmech.2019.02.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation