The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 6-(3-(1H-tetrazol-5-yl)phenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid

Summary for 6E3P

DescriptorPolymerase acidic protein, MANGANESE (II) ION, 3-hydroxy-4-oxo-6-[3-(1H-tetrazol-5-yl)phenyl]-1,4-dihydropyridine-2-carboxylic acid, ... (4 entities in total)
Functional Keywordspa endonuclease, inhibitor, influenza, h1n1, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceInfluenza A virus (strain swl A/California/04/2009 H1N1)
Total number of polymer chains1
Total molecular weight23177.03
Morrison, C.N.,Dick, B.L.,Credille, C.V.,Cohen, S.M. (deposition date: 2018-07-14, release date: 2019-07-17)
Primary citation
Credille, C.V.,Morrison, C.N.,Dick, B.L.,Stokes, R.W.,Cohen, S.M.
Development and Evaluation of Subnanomolar Inhibitors of PA Endonuclease
To Be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.30150 3.2%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution