6E3P
The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 6-(3-(1H-tetrazol-5-yl)phenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid
Summary for 6E3P
Entry DOI | 10.2210/pdb6e3p/pdb |
Descriptor | Polymerase acidic protein, MANGANESE (II) ION, 3-hydroxy-4-oxo-6-[3-(1H-tetrazol-5-yl)phenyl]-1,4-dihydropyridine-2-carboxylic acid, ... (4 entities in total) |
Functional Keywords | pa endonuclease, inhibitor, influenza, h1n1, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Influenza A virus (strain swl A/California/04/2009 H1N1) |
Total number of polymer chains | 1 |
Total formula weight | 23177.03 |
Authors | Morrison, C.N.,Dick, B.L.,Credille, C.V.,Cohen, S.M. (deposition date: 2018-07-14, release date: 2019-07-17, Last modification date: 2023-10-11) |
Primary citation | Credille, C.V.,Morrison, C.N.,Stokes, R.W.,Dick, B.L.,Feng, Y.,Sun, J.,Chen, Y.,Cohen, S.M. SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease. J.Med.Chem., 62:9438-9449, 2019 Cited by PubMed: 31536340DOI: 10.1021/acs.jmedchem.9b00747 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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