6E3N

The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-4-oxo-6-(o-tolyl)-1,4-dihydropyridine-2-carboxylic acid

6E3N の概要

• エントリーDOI: 10.2210/pdb6e3n/pdb
• 分子名称: Polymerase acidic protein, MANGANESE (II) ION, 3-hydroxy-6-(2-methylphenyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: pa endonuclease, inhibitor, influenza, h1n1, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Influenza A virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22823.77

構造登録者

Morrison, C.N.,Dick, B.L.,Credille, C.V.,Cohen, S.M. (登録日: 2018-07-14, 公開日: 2019-07-17, 最終更新日: 2024-03-13)

• 主引用文献: Credille, C.V.,Morrison, C.N.,Stokes, R.W.,Dick, B.L.,Feng, Y.,Sun, J.,Chen, Y.,Cohen, S.M.; SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease.; J.Med.Chem., 62:9438-9449, 2019; PubMed: 31536340; DOI: 10.1021/acs.jmedchem.9b00747

実験手法

X-RAY DIFFRACTION (3.19 Å)