6E2N

ASK1 kinase domain complex with inhibitor

6E2N の概要

• エントリーDOI: 10.2210/pdb6e2n/pdb
• 分子名称: Mitogen-activated protein kinase kinase kinase 5, N-[3-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)phenyl][3,4'-bipyridine]-2'-carboxamide (3 entities in total)
• 機能のキーワード: protein kinase, inhibitor complex, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67172.28

構造登録者

Lansdon, E.B. (登録日: 2018-07-11, 公開日: 2018-09-19, 最終更新日: 2018-10-17)

• 主引用文献: Liles, J.T.,Corkey, B.K.,Notte, G.T.,Budas, G.R.,Lansdon, E.B.,Hinojosa-Kirschenbaum, F.,Badal, S.S.,Lee, M.,Schultz, B.E.,Wise, S.,Pendem, S.,Graupe, M.,Castonguay, L.,Koch, K.A.,Wong, M.H.,Papalia, G.A.,French, D.M.,Sullivan, T.,Huntzicker, E.G.,Ma, F.Y.,Nikolic-Paterson, D.J.,Altuhaifi, T.,Yang, H.,Fogo, A.B.,Breckenridge, D.G.; ASK1 contributes to fibrosis and dysfunction in models of kidney disease.; J. Clin. Invest., 128:4485-4500, 2018; PubMed: 30024858; DOI: 10.1172/JCI99768

実験手法

X-RAY DIFFRACTION (2.098 Å)