6E0Q

The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid

6E0Q の概要

• エントリーDOI: 10.2210/pdb6e0q/pdb
• 分子名称: Polymerase acidic protein, MANGANESE (II) ION, 4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid, ... (5 entities in total)
• 機能のキーワード: inhibitor, endonuclease, influenza, pa domain, hydrolase-hydrolase inhibitor complex, viral protein, hydrolase/hydrolase inhibitor
• 由来する生物種: Influenza A virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22898.83

構造登録者

Dick, B.L.,Morrison, C.N.,Cohen, S.M. (登録日: 2018-07-06, 公開日: 2018-11-07, 最終更新日: 2023-10-11)

• 主引用文献: Credille, C.V.,Dick, B.L.,Morrison, C.N.,Stokes, R.W.,Adamek, R.N.,Wu, N.C.,Wilson, I.A.,Cohen, S.M.; Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease.; J. Med. Chem., 61:10206-10217, 2018; PubMed: 30351002; DOI: 10.1021/acs.jmedchem.8b01363

実験手法

X-RAY DIFFRACTION (2.35 Å)