6E0E

Crystal structure of Glucokinase in complex with compound 6

6E0E の概要

• エントリーDOI: 10.2210/pdb6e0e/pdb
• 分子名称: Glucokinase, alpha-D-glucopyranose, 2-({2-[(4-methyl-1,3-thiazol-2-yl)amino]pyridin-3-yl}oxy)benzonitrile, ... (4 entities in total)
• 機能のキーワード: glucokinase, glucokinase activator, structure-aided design, structure-based design, type ii diabetes, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 50752.55

構造登録者

Hinklin, R.J.,Baer, B.R.,Boyd, S.A.,Chicarelli, M.D.,Condroski, K.R.,DeWolf, W.E.,Fischer, J.,Frank, M.,Hingorani, G.P.,Lee, P.A.,Neitzel, N.A.,Pratt, S.A.,Singh, A.,Sullivan, F.X.,Turner, T.,Voegtli, W.C.,Wallace, E.M.,Williams, L.,Aicher, T.D. (登録日: 2018-07-06, 公開日: 2019-07-10, 最終更新日: 2024-03-13)

• 主引用文献: Hinklin, R.J.,Baer, B.R.,Boyd, S.A.,Chicarelli, M.D.,Condroski, K.R.,DeWolf Jr., W.E.,Fischer, J.,Frank, M.,Hingorani, G.P.,Lee, P.A.,Neitzel, N.A.,Pratt, S.A.,Singh, A.,Sullivan, F.X.,Turner, T.,Voegtli, W.C.,Wallace, E.M.,Williams, L.,Aicher, T.D.; Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.; Bioorg.Med.Chem., 28:115232-115232, 2020; PubMed: 31818630; DOI: 10.1016/j.bmc.2019.115232

実験手法

X-RAY DIFFRACTION (2.7 Å)