6DZW

Cryo-EM structure of the ts2-inactive human serotonin transporter in complex with paroxetine and 15B8 Fab and 8B6 ScFv

Summary for 6DZW

Entry DOI	10.2210/pdb6dzw/pdb
EMDB information	8941
Descriptor	Sodium-dependent serotonin transporter, 8B6 antibody single chain, 15B8 antibody heavy chain, ... (7 entities in total)
Functional Keywords	paroxetine, antidepressant, human serotonin transporter, fab, transport protein-immune system complex, transport protein/immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	112431.40
Authors	Coleman, J.A.,Yang, D.,Gouaux, E. (deposition date: 2018-07-05, release date: 2019-04-24, Last modification date: 2020-07-29)
Primary citation	Coleman, J.A.,Yang, D.,Zhao, Z.,Wen, P.C.,Yoshioka, C.,Tajkhorshid, E.,Gouaux, E. Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport. Nature, 569:141-145, 2019 Cited by PubMed: 31019304 DOI: 10.1038/s41586-019-1135-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.3 Å)

Structure validation