6DZV

Wild type human serotonin transporter in complex with 15B8 Fab bound to ibogaine in occluded conformation

Summary for 6DZV

• Entry DOI: 10.2210/pdb6dzv/pdb
• EMDB information: 8940
• Descriptor: Sodium-dependent serotonin transporter, 15B8 antibody heavy chain, 15B8 antibody light chain, ... (6 entities in total)
• Functional Keywords: ibogaine, human serotonin transporter, fab, transport protein-immune system complex, transport protein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 86655.89

Authors

Coleman, J.A.,Yang, D.,Gouaux, E. (deposition date: 2018-07-05, release date: 2019-04-24, Last modification date: 2020-07-29)

• Primary citation: Coleman, J.A.,Yang, D.,Zhao, Z.,Wen, P.C.,Yoshioka, C.,Tajkhorshid, E.,Gouaux, E.; Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.; Nature, 569:141-145, 2019; PubMed: 31019304; DOI: 10.1038/s41586-019-1135-1

Experimental method

ELECTRON MICROSCOPY (4.2 Å)