Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6DYA

WDR5 in complex with a WIN site inhibitor

Summary for 6DYA
Entry DOI10.2210/pdb6dya/pdb
DescriptorWD repeat-containing protein 5, N-[(3,5-dichlorophenyl)methyl]-3-[(1H-imidazol-1-yl)methyl]benzamide, SULFATE ION, ... (5 entities in total)
Functional Keywordswd40 repeat, epigenetics, mll binding, win site inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight34201.70
Authors
Phan, J.,Wang, F.,Fesik, S.W. (deposition date: 2018-07-01, release date: 2019-03-13, Last modification date: 2024-03-13)
Primary citationAho, E.R.,Wang, J.,Gogliotti, R.D.,Howard, G.C.,Phan, J.,Acharya, P.,Macdonald, J.D.,Cheng, K.,Lorey, S.L.,Lu, B.,Wenzel, S.,Foshage, A.M.,Alvarado, J.,Wang, F.,Shaw, J.G.,Zhao, B.,Weissmiller, A.M.,Thomas, L.R.,Vakoc, C.R.,Hall, M.D.,Hiebert, S.W.,Liu, Q.,Stauffer, S.R.,Fesik, S.W.,Tansey, W.P.
Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26:2916-2928.e13, 2019
Cited by
PubMed: 30865883
DOI: 10.1016/j.celrep.2019.02.047
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.56 Å)
Structure validation

217705

數據於2024-03-27公開中

PDB statisticsPDBj update infoContact PDBjnumon