6DYA

WDR5 in complex with a WIN site inhibitor

6DYA の概要

• エントリーDOI: 10.2210/pdb6dya/pdb
• 分子名称: WD repeat-containing protein 5, N-[(3,5-dichlorophenyl)methyl]-3-[(1H-imidazol-1-yl)methyl]benzamide, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: wd40 repeat, epigenetics, mll binding, win site inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34201.70

構造登録者

Phan, J.,Wang, F.,Fesik, S.W. (登録日: 2018-07-01, 公開日: 2019-03-13, 最終更新日: 2024-03-13)

• 主引用文献: Aho, E.R.,Wang, J.,Gogliotti, R.D.,Howard, G.C.,Phan, J.,Acharya, P.,Macdonald, J.D.,Cheng, K.,Lorey, S.L.,Lu, B.,Wenzel, S.,Foshage, A.M.,Alvarado, J.,Wang, F.,Shaw, J.G.,Zhao, B.,Weissmiller, A.M.,Thomas, L.R.,Vakoc, C.R.,Hall, M.D.,Hiebert, S.W.,Liu, Q.,Stauffer, S.R.,Fesik, S.W.,Tansey, W.P.; Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.; Cell Rep, 26:2916-2928.e13, 2019; PubMed: 30865883; DOI: 10.1016/j.celrep.2019.02.047

実験手法

X-RAY DIFFRACTION (2.56 Å)