6DY7
WDR5 in complex with a WIN site inhibitor
Summary for 6DY7
Entry DOI | 10.2210/pdb6dy7/pdb |
Descriptor | WD repeat-containing protein 5, N-[3-(2,4-dichlorophenoxy)propyl]-1H-imidazol-2-amine, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | wd40 repeat, epigenetic, wdr5-mll, win site, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 33952.37 |
Authors | Phan, J.,Wang, F.,Fesik, S.W. (deposition date: 2018-07-01, release date: 2019-03-13, Last modification date: 2024-03-13) |
Primary citation | Aho, E.R.,Wang, J.,Gogliotti, R.D.,Howard, G.C.,Phan, J.,Acharya, P.,Macdonald, J.D.,Cheng, K.,Lorey, S.L.,Lu, B.,Wenzel, S.,Foshage, A.M.,Alvarado, J.,Wang, F.,Shaw, J.G.,Zhao, B.,Weissmiller, A.M.,Thomas, L.R.,Vakoc, C.R.,Hall, M.D.,Hiebert, S.W.,Liu, Q.,Stauffer, S.R.,Fesik, S.W.,Tansey, W.P. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep, 26:2916-2928.e13, 2019 Cited by PubMed: 30865883DOI: 10.1016/j.celrep.2019.02.047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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