6DWD

SAMHD1 Bound to Clofarabine-TP in the Catalytic Pocket and Allosteric Pocket

6DWD の概要

• エントリーDOI: 10.2210/pdb6dwd/pdb
• 分子名称: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 9-{2-deoxy-2-fluoro-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-2-me thyl-9H-purin-6-amine, GUANOSINE-5'-TRIPHOSPHATE, ... (10 entities in total)
• 機能のキーワード: complex, deoxynucleoside triphosphate triphosphohydrolase, dntpase, nucleotide analogue, clofarabine-tp, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 261862.43

構造登録者

Knecht, K.M.,Buzovetsky, O.,Schneider, C.,Thomas, D.,Srikanth, V.,Kaderali, L.,Tofoleanu, F.,Reiss, K.,Ferreiros, N.,Geisslinger, G.,Batista, V.S.,Ji, X.,Cinatl, J.,Keppler, O.T.,Xiong, Y. (登録日: 2018-06-26, 公開日: 2018-10-10, 最終更新日: 2024-03-13)

• 主引用文献: Knecht, K.M.,Buzovetsky, O.,Schneider, C.,Thomas, D.,Srikanth, V.,Kaderali, L.,Tofoleanu, F.,Reiss, K.,Ferreiros, N.,Geisslinger, G.,Batista, V.S.,Ji, X.,Cinatl Jr., J.,Keppler, O.T.,Xiong, Y.; The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.; Proc. Natl. Acad. Sci. U.S.A., 115:E10022-E10031, 2018; PubMed: 30305425; DOI: 10.1073/pnas.1805593115

実験手法

X-RAY DIFFRACTION (1.7 Å)