6DVM

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with DDK-122

Summary for 6DVM

Entry DOI	10.2210/pdb6dvm/pdb
Descriptor	Hdac6 protein, ZINC ION, POTASSIUM ION, ... (7 entities in total)
Functional Keywords	histone deacetylaase, metallohydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	4
Total formula weight	164574.58
Authors	Porter, N.J.,Christianson, D.W. (deposition date: 2018-06-24, release date: 2018-08-29, Last modification date: 2024-03-13)
Primary citation	Porter, N.J.,Osko, J.D.,Diedrich, D.,Kurz, T.,Hooker, J.M.,Hansen, F.K.,Christianson, D.W. Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity. J. Med. Chem., 61:8054-8060, 2018 Cited by PubMed: 30118224 DOI: 10.1021/acs.jmedchem.8b01013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.47 Å)

Structure validation