6DUD

JAK3 with cyanamide CP12

Summary for 6DUD

Entry DOI	10.2210/pdb6dud/pdb
Descriptor	Tyrosine-protein kinase JAK3, N-[(1S)-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]imidoformamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	kinase, covalent, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	36917.04
Authors	Vajdos, F.F. (deposition date: 2018-06-20, release date: 2018-11-28, Last modification date: 2024-04-03)
Primary citation	Casimiro-Garcia, A.,Trujillo, J.I.,Vajdos, F.,Juba, B.,Banker, M.E.,Aulabaugh, A.,Balbo, P.,Bauman, J.,Chrencik, J.,Coe, J.W.,Czerwinski, R.,Dowty, M.,Knafels, J.D.,Kwon, S.,Leung, L.,Liang, S.,Robinson, R.P.,Telliez, J.B.,Unwalla, R.,Yang, X.,Thorarensen, A. Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. J. Med. Chem., 61:10665-10699, 2018 Cited by PubMed: 30423248 DOI: 10.1021/acs.jmedchem.8b01308 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.66 Å)

Structure validation