6DTW

HIV-1 Reverse Transcriptase Y181C Mutant in complex with JLJ 578

6DTW の概要

• エントリーDOI: 10.2210/pdb6dtw/pdb
• 分子名称: Reverse transcriptase/ribonuclease H, p51 RT, 8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-fluorophenoxy}-6-fluoroindolizine-2-carbonitrile, ... (6 entities in total)
• 機能のキーワード: hiv-1, reverse transcriptase, inhibitor, hydrolase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 group M subtype B (isolate BH10); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114513.42

構造登録者

Sasaki, T.,Gannam, Z.T.K.,Anderson, K.S.,Jorgensen, W.L.,Lee, W. (登録日: 2018-06-18, 公開日: 2019-07-31, 最終更新日: 2023-10-11)

• 主引用文献: Sasaki, T.,Gannam, Z.T.K.,Kudalkar, S.N.,Frey, K.M.,Lee, W.G.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S.; Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase.; Bioorg.Med.Chem.Lett., 29:2182-2188, 2019; PubMed: 31281023; DOI: 10.1016/j.bmcl.2019.06.047

実験手法

X-RAY DIFFRACTION (2.742 Å)