6DQD

LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N53 i.e. 2-(5-([1,1'-biphenyl]-3-yl)-4-(1-(2-(piperidin-1-yl)ethoxy)ethyl)-1H-pyrazol-1-yl)isonicotinic acid

Summary for 6DQD

• Entry DOI: 10.2210/pdb6dqd/pdb
• Descriptor: Linked KDM5A Jmj Domain, 2-[5-([1,1'-biphenyl]-3-yl)-4-{(1S)-1-[2-(piperidin-1-yl)ethoxy]ethyl}-1H-pyrazol-1-yl]pyridine-4-carboxylic acid, MANGANESE (II) ION, ... (6 entities in total)
• Functional Keywords: demethylase inhibition, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 38836.83

Authors

Horton, J.R.,Cheng, X. (deposition date: 2018-06-10, release date: 2019-06-12, Last modification date: 2023-10-11)

• Primary citation: Horton, J.R.,Liu, X.,Woodcock, C.B.,Shanks, J.,Zhang, X.,Rai, G.,Mott, B.,Jansen, D.J.,Kales, S.,Henderson, M.J.,Pohida, K.,Fang, Y.,Hu, X.,Jadhav, A.,Maloney, D.,Hall, M.D.,Simeonov, A.,Fu, H.,Vertino, P.M.,Cheng, X.; To be determined; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.987 Å)