6DND
Crystal structure of wild-type (WT) human Glutamate oxaloacetate transaminase 1 (GOT1)
Summary for 6DND
| Entry DOI | 10.2210/pdb6dnd/pdb |
| Descriptor | Aspartate aminotransferase, cytoplasmic, TETRAETHYLENE GLYCOL, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total) |
| Functional Keywords | aspartate aminotransferase, glutamate oxaloacetate transaminase 1, got1, plp, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 93076.81 |
| Authors | Assar, Z.,Holt, M.C.,Stein, A.J.,Lairson, L.,Lyssiotis, C.A. (deposition date: 2018-06-06, release date: 2018-11-14, Last modification date: 2023-10-11) |
| Primary citation | Holt, M.C.,Assar, Z.,Beheshti Zavareh, R.,Lin, L.,Anglin, J.,Mashadova, O.,Haldar, D.,Mullarky, E.,Kremer, D.M.,Cantley, L.C.,Kimmelman, A.C.,Stein, A.J.,Lairson, L.L.,Lyssiotis, C.A. Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry, 57:6604-6614, 2018 Cited by PubMed: 30365304DOI: 10.1021/acs.biochem.8b00914 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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