6DGT

Selective PI3K beta inhibitor bound to PI3K delta

6DGT の概要

• エントリーDOI: 10.2210/pdb6dgt/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine (3 entities in total)
• 機能のキーワード: pi3k delta, p110, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 108110.90

構造登録者

Somoza, J.,Villasenor, A.,McGrath, M. (登録日: 2018-05-18, 公開日: 2018-08-01, 最終更新日: 2024-03-13)

• 主引用文献: Chandrasekhar, J.,Dick, R.,Van Veldhuizen, J.,Koditek, D.,Lepist, E.I.,McGrath, M.E.,Patel, L.,Phillips, G.,Sedillo, K.,Somoza, J.R.,Therrien, J.,Till, N.A.,Treiberg, J.,Villasenor, A.G.,Zherebina, Y.,Perreault, S.; Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) beta Inhibitor.; J. Med. Chem., 61:6858-6868, 2018; PubMed: 30015489; DOI: 10.1021/acs.jmedchem.8b00797

実験手法

X-RAY DIFFRACTION (2.601 Å)