6DGO

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Troglitazone

Summary for 6DGO

DescriptorPeroxisome proliferator-activated receptor gamma, (5S)-5-[(4-{[(2R)-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-yl]methoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione (2 entities in total)
Functional Keywordsnuclear receptors, tzds, drug design, therapeutic targets, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight63340.58
Authors
Shang, J.,Kojetin, D.J. (deposition date: 2018-05-17, release date: 2019-05-22)
Primary citation
Shang, J.,Kojetin, D.J.
Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Troglitazone
To Be Published,
Experimental method
X-RAY DIFFRACTION (3.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27613 1.8% 3.0% 1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution