6DG2

Antigen Binding Fragment of the Pan-ebolavirus Monoclonal Antibody 6D6

6DG2 の概要

• エントリーDOI: 10.2210/pdb6dg2/pdb
• 分子名称: 6D6 Fab heavy chain, 6D6 Fab light chain (3 entities in total)
• 機能のキーワード: antibody, monoclonal, antigen binding fragment, fab, ebola, immune system
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 96755.61

構造登録者

Milligan, J.C.,Saphire, E.O. (登録日: 2018-05-16, 公開日: 2018-09-26, 最終更新日: 2024-10-23)

主引用文献

Milligan, J.C.,Parekh, D.V.,Fuller, K.M.,Igarashi, M.,Takada, A.,Saphire, E.O.
Structural Characterization of Pan-Ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein.
J. Infect. Dis., 219:415-419, 2019

PubMed Abstract: Ebola virus infection causes severe disease in humans and represents a global health threat. Candidates for immunotherapeutics and vaccines have shown promise in clinical trials, although they are ineffective against other members of the Ebolavirus genus that also cause periodic, lethal outbreaks. In this study, we present a crystal structure of a pan-ebolavirus antibody, 6D6, as well as single-particle electron microscopy reconstructions of 6D6 in complex with Ebola and Bundibugyo virus glycoproteins. 6D6 binds to the conserved glycoprotein fusion peptide, implicating it as a site of immune vulnerability that could be exploited to reliably elicit a pan-ebolavirus neutralizing antibody response.

PubMed: 30203042
DOI: 10.1093/infdis/jiy532

実験手法

X-RAY DIFFRACTION (1.96 Å)