6DF6
Crystal structure of estrogen receptor alpha in complex with receptor degrader 16ab
Summary for 6DF6
Entry DOI | 10.2210/pdb6df6/pdb |
Descriptor | Estrogen receptor, (8R)-8-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-1,8-dihydro-2H-[1]benzopyrano[4,3-d][1]benzoxepine-5,11-diol, GLYCEROL, ... (4 entities in total) |
Functional Keywords | era, antagonist, inverse agonist, receptor, breast cancer, degrader, ligand, estrogen receptor, nuclear protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 130063.51 |
Authors | Kiefer, J.R.,Vinogradova, M.,Liang, J.,Zhang, B.,Ortwine, D.F.,Nettles, K.W.,Nwachukwu, J.C. (deposition date: 2018-05-14, release date: 2019-02-20, Last modification date: 2024-03-13) |
Primary citation | Zhang, B.,Kiefer, J.R.,Blake, R.A.,Chang, J.H.,Hartman, S.,Ingalla, E.R.,Kleinheinz, T.,Mody, V.,Nannini, M.,Ortwine, D.F.,Ran, Y.,Sambrone, A.,Sampath, D.,Vinogradova, M.,Zhong, Y.,Nwachukwu, J.C.,Nettles, K.W.,Lai, T.,Liao, J.,Zheng, X.,Chen, H.,Wang, X.,Liang, J. Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. Bioorg. Med. Chem. Lett., 29:905-911, 2019 Cited by PubMed: 30732944DOI: 10.1016/j.bmcl.2019.01.036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report