6DES

Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone

6DES の概要

• エントリーDOI: 10.2210/pdb6des/pdb
• 分子名称: Acetolactate synthase, FLAVIN-ADENINE DINUCLEOTIDE, POTASSIUM ION, ... (7 entities in total)
• 機能のキーワード: ahas, acetohydroxyacid synthase, acetolactate synthase, herbicide, thiamin diphosphate, fad, transferase, propoxycarbazone, sulfonylamino-carbonyl-triazolinone, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 76003.02

構造登録者

Garcia, M.D.,Guddat, L.W. (登録日: 2018-05-12, 公開日: 2018-09-26, 最終更新日: 2023-10-11)

• 主引用文献: Garcia, M.D.,Chua, S.M.H.,Low, Y.S.,Lee, Y.T.,Agnew-Francis, K.,Wang, J.G.,Nouwens, A.,Lonhienne, T.,Williams, C.M.,Fraser, J.A.,Guddat, L.W.; Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.; Proc. Natl. Acad. Sci. U.S.A., 115:E9649-E9658, 2018; PubMed: 30249642; DOI: 10.1073/pnas.1809422115

実験手法

X-RAY DIFFRACTION (2.402 Å)