6DE3

Crystal structure of the double mutant (R39Q/D52N) of the full-length NT5C2 in the active state

6DE3 の概要

• エントリーDOI: 10.2210/pdb6de3/pdb
• 分子名称: Cytosolic purine 5'-nucleotidase, PHOSPHATE ION, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 67553.13

構造登録者

Forouhar, F.,Dieck, C.L.,Tzoneva, G.,Carpenter, Z.,Ambesi-Impiombato, A.,Sanchez-Martin, M.,Kirschner-Schwabe, R.,Lew, S.,Seetharaman, J.,Ferrando, A.A.,Tong, L. (登録日: 2018-05-11, 公開日: 2018-07-04, 最終更新日: 2023-10-11)

• 主引用文献: Dieck, C.L.,Tzoneva, G.,Forouhar, F.,Carpenter, Z.,Ambesi-Impiombato, A.,Sanchez-Martin, M.,Kirschner-Schwabe, R.,Lew, S.,Seetharaman, J.,Tong, L.,Ferrando, A.A.; Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.; Cancer Cell, 34:136-147.e6, 2018; PubMed: 29990496; DOI: 10.1016/j.ccell.2018.06.003

実験手法

X-RAY DIFFRACTION (3.06 Å)