6D8Z

Crystal Structure of the C-terminal Guanine Nucleotide Exchange Factor Module of Human Trio

Summary for 6D8Z

Entry DOI	10.2210/pdb6d8z/pdb
Descriptor	Triple functional domain protein (2 entities in total)
Functional Keywords	rhogef, dbl family member, dbl homology, pleckstrin homology, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	112446.82
Authors	Bandekar, S.,Tesmer, J.J. (deposition date: 2018-04-27, release date: 2019-02-20, Last modification date: 2023-10-04)
Primary citation	Bandekar, S.J.,Arang, N.,Tully, E.S.,Tang, B.A.,Barton, B.L.,Li, S.,Gutkind, J.S.,Tesmer, J.J.G. Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential. Sci Signal, 12:-, 2019 Cited by PubMed: 30783010 DOI: 10.1126/scisignal.aav2449 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation