6D8Z
Crystal Structure of the C-terminal Guanine Nucleotide Exchange Factor Module of Human Trio
Summary for 6D8Z
Entry DOI | 10.2210/pdb6d8z/pdb |
Descriptor | Triple functional domain protein (2 entities in total) |
Functional Keywords | rhogef, dbl family member, dbl homology, pleckstrin homology, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 112446.82 |
Authors | Bandekar, S.,Tesmer, J.J. (deposition date: 2018-04-27, release date: 2019-02-20, Last modification date: 2023-10-04) |
Primary citation | Bandekar, S.J.,Arang, N.,Tully, E.S.,Tang, B.A.,Barton, B.L.,Li, S.,Gutkind, J.S.,Tesmer, J.J.G. Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential. Sci Signal, 12:-, 2019 Cited by PubMed: 30783010DOI: 10.1126/scisignal.aav2449 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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