6D8Z

Crystal Structure of the C-terminal Guanine Nucleotide Exchange Factor Module of Human Trio

6D8Z の概要

• エントリーDOI: 10.2210/pdb6d8z/pdb
• 分子名称: Triple functional domain protein (2 entities in total)
• 機能のキーワード: rhogef, dbl family member, dbl homology, pleckstrin homology, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 112446.82

構造登録者

Bandekar, S.,Tesmer, J.J. (登録日: 2018-04-27, 公開日: 2019-02-20, 最終更新日: 2023-10-04)

• 主引用文献: Bandekar, S.J.,Arang, N.,Tully, E.S.,Tang, B.A.,Barton, B.L.,Li, S.,Gutkind, J.S.,Tesmer, J.J.G.; Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential.; Sci Signal, 12:-, 2019; PubMed: 30783010; DOI: 10.1126/scisignal.aav2449

実験手法

X-RAY DIFFRACTION (2.65 Å)