6D8E
Discovery of a Highly Potent and Broadly Effective EGFR and HER2 Exon 20 Insertion Mutant Inhibitor
Summary for 6D8E
Entry DOI | 10.2210/pdb6d8e/pdb |
Descriptor | Epidermal growth factor receptor, (4-fluorophenyl)methyl {2-[(1-methyl-1H-pyrazol-3-yl)amino]pyrimidin-4-yl}[3-(propanoylamino)phenyl]carbamate (3 entities in total) |
Functional Keywords | egfr, inhibitor, signaling protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 37793.63 |
Authors | |
Primary citation | Jang, J.,Son, J.,Park, E.,Kosaka, T.,Saxon, J.A.,De Clercq, D.J.H.,Choi, H.G.,Tanizaki, J.,Eck, M.J.,Janne, P.A.,Gray, N.S. Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor. Angew. Chem. Int. Ed. Engl., 57:11629-11633, 2018 Cited by PubMed: 29978938DOI: 10.1002/anie.201805187 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.537 Å) |
Structure validation
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